Coronavirus Replication in Host Cells

September 22nd 2020

Within the last 2 decades, there have been 3 potentially lethal coronavirus outbreaks for humans including SARS-CoV-2 which causes COVID-19. Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored micro-environment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and mRNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions.

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